Progress in pharmacologic management of neuropsychiatric syndromes in neurodegenerative disorders: a review

J Cummings, K Lanctot, G Grossberg… - JAMA neurology, 2024 - jamanetwork.com
Importance Neuropsychiatric syndromes (NPSs) are common in neurodegenerative
disorders (NDDs); compromise the quality of life of patients and their care partners; and are …

A transdiagnostic review of neuroimaging studies of apathy and disinhibition in dementia

LM Jenkins, L Wang, H Rosen, S Weintraub - Brain, 2022 - academic.oup.com
Apathy and disinhibition are common and highly distressing neuropsychiatric symptoms
associated with negative outcomes in persons with dementia. This paper is a critical review …

Loneliness and risk of all-cause, Alzheimer's, vascular, and frontotemporal dementia: a prospective study of 492,322 individuals over 15 years

AR Sutin, M Luchetti, D Aschwanden, X Zhu… - International …, 2023 - cambridge.org
Objectives: This study examined the association between loneliness and risk of incident all-
cause dementia and whether the association extends to specific causes of dementia …

The beneficial role of apigenin against cognitive and neurobehavioural dysfunction: a systematic review of preclinical investigations

TA Olasehinde, OO Olaokun - Biomedicines, 2024 - mdpi.com
Apigenin is a flavone widely present in different fruits and vegetables and has been
suggested to possess neuroprotective effects against some neurological disorders. In this …

Acetylcholine deficit causes dysfunctional inhibitory control in an aging-dependent manner

PR Sabandal, EB Saldes, KA Han - Scientific Reports, 2022 - nature.com
Inhibitory control is a key executive function that limits unnecessary thoughts and actions,
enabling an organism to appropriately execute goal-driven behaviors. The efficiency of this …

Identification of the main components of spontaneous speech in primary progressive aphasia and their neural underpinnings using multimodal MRI and FDG-PET …

JA Matias-Guiu, P Suárez-Coalla, M Yus, V Pytel… - Cortex, 2022 - Elsevier
Background Primary progressive aphasia (PPA) is a clinical syndrome characterized by
gradual loss of language skills. This study aimed to evaluate the diagnostic capacity of a …

Biosensors toward behavior detection in diagnosis of alzheimer's disease

X Sun, X Sun, Q Wang, X Wang, L Feng… - … in Bioengineering and …, 2022 - frontiersin.org
In recent years, a huge number of individuals all over the world, elderly people, in particular,
have been suffering from Alzheimer's disease (AD), which has had a significant negative …

Altered delay discounting in neurodegeneration: insight into the underlying mechanisms and perspectives for clinical applications

V Godefroy, I Sezer, A Bouzigues… - Neuroscience & …, 2023 - Elsevier
Steeper delay discounting (ie, the extent to which future rewards are perceived as less
valuable than immediate ones) has been proposed as a transdiagnostic process across …

Behavioral variant frontotemporal dementia and social and criminal transgressions

MF Mendez - The Journal of Neuropsychiatry and Clinical …, 2022 - psychiatryonline.org
Objective: Behavioral variant frontotemporal dementia (bvFTD) is associated with social and
criminal transgressions; studies from countries around the world have documented such …

Disinhibition in dementia related to reduced morphometric similarity of cognitive control network

LM Jenkins, A Heywood, S Gupta… - Brain …, 2024 - academic.oup.com
Disinhibition is one of the most distressing and difficult to treat neuropsychiatric symptoms of
dementia. It involves socially inappropriate behaviours, such as hypersexual comments …