Immunological lessons from respiratory syncytial virus vaccine development

TJ Ruckwardt, KM Morabito, BS Graham - Immunity, 2019 - cell.com
Respiratory syncytial virus (RSV) has eluded active vaccination efforts for more than five
decades and continues to cause substantial morbidity and mortality in infants, the …

Biology of infection and disease pathogenesis to guide RSV vaccine development

S Boyoglu-Barnum, T Chirkova… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract disease
in young children and a substantial contributor to respiratory tract disease throughout life …

[HTML][HTML] Biomimetic metal-organic frameworks as protective scaffolds for live-virus encapsulation and vaccine stabilization

R Singh, JF White, M de Vries, G Beddome, M Dai… - Acta Biomaterialia, 2022 - Elsevier
The invaluable health, economic and social impacts of vaccination are hard to exaggerate.
The ability to stabilize vaccines is urgently required for their equitable distribution without the …

Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2

MF Tioni, R Jordan, AS Pena, A Garg, D Wu, SI Phan… - npj Vaccines, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the COVID-19 global pandemic. SARS-CoV-2 is an enveloped RNA virus that relies on its …

A contemporary view of respiratory syncytial virus (RSV) biology and strain-specific differences

MC Pandya, SM Callahan, KG Savchenko, CC Stobart - Pathogens, 2019 - mdpi.com
Respiratory syncytial virus (RSV) is a human respiratory pathogen which remains a leading
viral cause of hospitalizations and mortality among infants in their first year of life. Here, we …

High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers

I del Moral-Sánchez, RA Russell, EE Schermer… - npj Vaccines, 2022 - nature.com
Soluble HIV-1 envelope glycoprotein (Env) immunogens are a prime constituent of
candidate vaccines designed to induce broadly neutralizing antibodies. Several lines of …

Respiratory syncytial virus infection: treatments and clinical management

S Malik, T Ahmad, K Muhammad, Y Waheed - Vaccines, 2023 - mdpi.com
Respiratory syncytial virus (RSV) is a major healthcare concern, especially for immune-
compromised individuals and infants below 5 years of age. Worldwide, it is known to be …

Mucosal application of a low-energy electron inactivated respiratory syncytial virus vaccine shows protective efficacy in an animal model

V Eberlein, M Ahrends, L Bayer, J Finkensieper… - Viruses, 2023 - mdpi.com
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract
infections in the elderly and in children, associated with pediatric hospitalizations. Recently …

Attenuation of human respiratory viruses by synonymous genome recoding

C Le Nouën, PL Collins, UJ Buchholz - Frontiers in Immunology, 2019 - frontiersin.org
Using computer algorithms and commercial DNA synthesis, one or more ORFs of a
microbial pathogen such as a virus can be recoded and deoptimized by several strategies …

An epitope-specific chemically defined nanoparticle vaccine for respiratory syncytial virus

A Zuniga, O Rassek, M Vrohlings, A Marrero-Nodarse… - NPJ vaccines, 2021 - nature.com
Respiratory syncytial virus (RSV) can cause severe respiratory disease in humans,
particularly in infants and the elderly. However, attempts to develop a safe and effective …