During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …

The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …

Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …

Background The immunosenescence is a relatively recent chapter, correlated with the linear
extension of the average life began in the nineteenth century and still in progress. The most …

Background: Chronic inflammation plays a significant role in accelerating the aging process
and is closely associated with the initiation and progression of a broad range of age-related …

Background Age-related physiological changes in the gastrointestinal tract, as well as
modifications in lifestyle, nutritional behaviour, and functionality of the host immune system …

Owing to its memory and plasticity, the immune system (IS) is capable of recording all the
immunological experiences and stimuli it was exposed to. The combination of type, dose …

Calorie restriction has been regarded as the only experimental regimen that can effectively
lengthen lifespan in various animal models, but the actual mechanism remains …

Disruption of the gut microbiota by high-fat diet (HFD) has been implicated in the
development of obesity. It remains to be elucidated whether the HFD-induced shifts occur at …

The gut microbiota (GM) is a complex, evolutionarily molded ecological system, which
contributes to a variety of physiological functions. The GM is highly dynamic, being sensitive …