1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

Radical-involved transition metal (TM) catalysis has greatly enabled new reactivities in
recent decades. Copper-catalyzed radical relay offers enormous potential in C (sp3)–H …

C–H functionalization reactions are playing an increasing role in the preparation and
modification of complex organic molecules, including pharmaceuticals, agrochemicals and …

Radical C–H functionalization represents a useful means of streamlining synthetic routes by
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …

Asymmetric sp3 C–H functionalization has been demonstrated to substantially expedite
target molecule synthesis, spanning from feedstocks upgradation to late-stage modification …

The construction of carbon–heteroatom bonds is one of the most active areas of research in
organic chemistry because the function of organic molecules is often derived from the …

Copper-catalyzed radical-relay reactions provide a versatile strategy for selective C–H
functionalization; however, reactions with peroxide-based oxidants often require excess C …

Methods that enable site selective acylation of sp3 CH bonds in complex organic molecules
are not well explored, particularly if compared with analogous transformations of aromatic …

The C–O bond is ubiquitous in biologically active molecules, pharmaceutical agents, and
functional materials, thereby making it an important functional group. Consequently, the …