[HTML][HTML] Monogenic Parkinson's disease: genotype, phenotype, pathophysiology, and genetic testing
Genes | Free Full-Text | Monogenic Parkinson’s Disease: Genotype, Phenotype,
Pathophysiology, and Genetic Testing Next Article in Journal enChIP-Seq Analyzer: A …
Pathophysiology, and Genetic Testing Next Article in Journal enChIP-Seq Analyzer: A …
MicroRNA dysregulation in Parkinson's disease: a narrative review
Parkinson's disease (PD) is a severely debilitating neurodegenerative disease, affecting the
motor system, leading to resting tremor, cogwheel rigidity, bradykinesia, walking and gait …
motor system, leading to resting tremor, cogwheel rigidity, bradykinesia, walking and gait …
Defining the riddle in order to solve it: there is more than one “Parkinson's disease”
Background More than 200 years after James Parkinsondescribed a clinical syndrome
based on his astute observations, Parkinson's disease (PD) has evolved into a complex …
based on his astute observations, Parkinson's disease (PD) has evolved into a complex …
Long‐Read Sequencing Resolves a Complex Structural Variant in PRKN Parkinson's Disease
Abstract Background Parkin RBR E3 ubiquitin‐protein ligase (PRKN) mutations are the most
common cause of young onset and autosomal recessive Parkinson's disease (PD). PRKN is …
common cause of young onset and autosomal recessive Parkinson's disease (PD). PRKN is …
Towards a global view of Parkinson's disease genetics
Parkinson's disease (PD) is a global health challenge, yet historically studies of PD have
taken place predominantly in European populations. Recent genetics research conducted in …
taken place predominantly in European populations. Recent genetics research conducted in …
Differences in survival across monogenic forms of Parkinson's disease
A Lanore, F Casse, C Tesson, T Courtin… - Annals of …, 2023 - Wiley Online Library
Objective Survival of patients with monogenic Parkinson's disease may depend on the
causative genes associated with the disease. In this study, we compare survival of patients …
causative genes associated with the disease. In this study, we compare survival of patients …
Uncovering the genetic basis of Parkinson's disease globally: from discoveries to the clinic
Knowledge on the genetic basis of Parkinson's disease has grown tremendously since the
discovery of the first monogenic form, caused by a mutation in α-synuclein, and with the …
discovery of the first monogenic form, caused by a mutation in α-synuclein, and with the …
Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites
JM Tokarew, DN El-Kodsi, NA Lengacher, TK Fehr… - Acta …, 2021 - Springer
The mechanisms by which parkin protects the adult human brain from Parkinson disease
remain incompletely understood. We hypothesized that parkin cysteines participate in redox …
remain incompletely understood. We hypothesized that parkin cysteines participate in redox …
Genotype–phenotype correlation in PRKN-associated Parkinson's disease
PJ Menon, S Sambin, B Criniere-Boizet… - npj Parkinson's …, 2024 - nature.com
Bi-allelic pathogenic variants in PRKN are the most common cause of autosomal recessive
Parkinson's disease (PD). 647 patients with PRKN-PD were included in this international …
Parkinson's disease (PD). 647 patients with PRKN-PD were included in this international …
[HTML][HTML] Parkinson's disease updates: Addressing the pathophysiology, risk factors, genetics, diagnosis, along with the medical and surgical treatment
P Prajjwal, HSF Sanga, K Acharya… - Annals of Medicine …, 2023 - journals.lww.com
After only Alzheimer's disease (AD), Parkinson's disease (PD) is the second most prevalent
neurodegenerative disease. The incidence of this disease increases with age, especially for …
neurodegenerative disease. The incidence of this disease increases with age, especially for …