Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …

Fragile X syndrome (FXS) results from a genetic mutation in a single gene yet produces a
phenotypically complex disorder with a range of neurological and psychiatric problems …

Neurons in the suprachiasmatic nucleus (SCN) function as part of a central timing circuit that
drives daily changes in our behaviour and underlying physiology. A hallmark feature of SCN …

Circadian clocks organize behavior and physiology to adapt to daily environmental cycles.
Genetic approaches in the fruit fly, Drosophila melanogaster, have revealed widely …

Subtle alterations in how cortical network dynamics are modulated by different behavioral
states could disrupt normal brain function and underlie symptoms of neuropsychiatric …

Sleep homeostasis is a complex neurobiologic phenomenon involving a number of
molecular pathways, neurotransmitter release, synaptic activity, and factors modulating …

Loss of the RNA binding protein FMRP causes Fragile X Syndrome (FXS), the most common
cause of inherited intellectual disability, yet it is unknown how FMRP function varies across …

There has been considerable progress in elucidating the molecular mechanisms that
contribute to memory formation and the generation of circadian rhythms. However, it is not …

To uncover shared pathogenic mechanisms among the highly heterogeneous autism
spectrum disorders (ASDs), we developed a protein interaction network that identified …

Fragile X syndrome (FXS) is a neurodevelopmental disorder that causes intellectual
disability. It is a leading known genetic cause of autism. In addition to cognitive, social, and …