[HTML][HTML] Social brain, social dysfunction and social withdrawal

S Porcelli, N Van Der Wee, S van der Werff… - Neuroscience & …, 2019‏ - Elsevier
The human social brain is complex. Current knowledge fails to define the neurobiological
processes underlying social behaviour involving the (patho-) physiological mechanisms that …

Schizophrenia: an integrated sociodevelopmental-cognitive model

OD Howes, RM Murray - The Lancet, 2014‏ - thelancet.com
Schizophrenia remains a major burden on patients and society. The dopamine hypothesis
attempts to explain the pathogenic mechanisms of the disorder, and the …

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

CM Sellgren, J Gracias, B Watmuff, JD Biag… - Nature …, 2019‏ - nature.com
Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which
is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of …

Beyond the “at risk mental state” concept: transitioning to transdiagnostic psychiatry

PD McGorry, JA Hartmann, R Spooner… - World …, 2018‏ - Wiley Online Library
The “at risk mental state” for psychosis approach has been a catalytic, highly productive
research paradigm over the last 25 years. In this paper we review that paradigm and …

The psychosis high-risk state: a comprehensive state-of-the-art review

P Fusar-Poli, S Borgwardt, A Bechdolf… - JAMA …, 2013‏ - jamanetwork.com
Context During the past 2 decades, a major transition in the clinical characterization of
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …

Progressive reduction in cortical thickness as psychosis develops: a multisite longitudinal neuroimaging study of youth at elevated clinical risk

TD Cannon, Y Chung, G He, D Sun, A Jacobson… - Biological …, 2015‏ - Elsevier
Background Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms
have been observed to show a steeper rate of cortical gray matter reduction compared with …

The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological …

M Pruessner, AE Cullen, M Aas, EF Walker - … & Biobehavioral Reviews, 2017‏ - Elsevier
Over the past decade, our understanding of the role of stress in serious mental illness has
become more sophisticated. In this paper, we revisit the neural diathesis-stress model of …

Association of structural magnetic resonance imaging measures with psychosis onset in individuals at clinical high risk for develo** psychosis: an ENIGMA working …

M Jalbrzikowski, RA Hayes, SJ Wood… - JAMA …, 2021‏ - jamanetwork.com
Importance The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …

[كتاب][B] Neuro: The new brain sciences and the management of the mind

N Rose, JM Abi-Rached - 2013‏ - degruyter.com
The brain sciences are influencing our understanding of human behavior as never before,
from neuropsychiatry and neuroeconomics to neurotheology and neuroaesthetics. Many …

Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia

DA Lewis, AA Curley, JR Glausier, DW Volk - Trends in neurosciences, 2012‏ - cell.com
Deficits in cognitive control, a core disturbance of schizophrenia, appear to emerge from
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …