Phenotypic trait values in 166 healthy white subjects (age range, 18 to 88 years) were
determined for dapsone N‐hydroxylation, dapsone N‐acetylation, debrisoquin 4 …

Objectives: Induction or inhibition of cytochrome P450 (CYP) enzyme activities, enzymes
that activate or detoxify xenobiotics, is one mechanism by which vegetables may alter …

N-Acetylation is a phase II conjugation reaction mediated in humans by the polymorphic N-
acetyltransferase 2 (NAT2) and N-acetyltransferase 1 (NAT1). Acetylation of some drugs …

The present study aimed to identify the NAT2 haplotypes, linkage disequilibrium, and novel
NAT2 genetic variants among Jordanian population. We isolated the genomic DNA from 68 …

Background N-acetyltransferase 2 (NAT2) enzyme is a Phase II drug-metabolizing enzyme
that metabolizes different compounds. Genetic variations in NAT2 can influence the …

Background Isoniazid (INH) is the mainstay antimicrobial in the treatment of tuberculosis
(TB). It is acetlylated in the liver to acetyl-INH. However, there is variation in rate of …

Introduction: There is a variation in drug response among patients who practice intermittent
fasting. Alteration in the expression of drug-metabolizing enzymes (DMEs) can affect the …

Aims: The present study is designed to investigate the acetylator status in Saudi Arabs.
Methods: Isoniazid (INH) acetylation phenoty** was studied in 136 Saudi Arabs in Riyadh …

Objective: To determine the frequency of major NAT2 alleles and genotypes among the
Jordanian population. Methods: DNA samples from 150 healthy Jordanian volunteers were …

Age-distribution and genotype-phenotype correlation for N-acetyltransferase in Argentine
children under isoniazid treatment. - Abstract - Europe PMC Sign in | Create an account …