Colloidal drug delivery systems have been extensively investigated as drug carriers for the
application of different drugs via different routes of administration. Systems, such as solid …

Air− liquid interface (ALI) culture models currently represent a valid instrument to recreate
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …

Mucus is a complex hydrogel that acts as a natural barrier to drug delivery at different
mucosal surfaces including the respiratory, gastrointestinal, and vaginal tracts. To elucidate …

The epithelium that covers the conducting airways and alveoli is a primary target for inhaled
toxic substances, and therefore a focus in inhalation toxicology. The increasing concern …

Despite the interest in systemic delivery of therapeutic molecules including macromolecular
proteins and peptides via the lung, the accurate assessment of their pulmonary …

Recent developments in delivering drugs to the lung are driving the need for in vitro
methods to evaluate the fate of inhaled medicines. Constraints on experimentation using …

The nasal route has been used for many years for the local treatment of nasal diseases.
More recently, this route has been gaining momentum, due to the possibility of targeting the …

The receptor for advanced glycation endproducts (RAGE) is expressed under pathological
conditions in many tissues and has been assigned many functions. We demonstrate, in …

This paper describes a new human alveolar epithelial cell line (hAELVi–human Alveolar
Epithelial Lentivirus immortalized) with type I-like characteristics and functional tight …

Models of the outer epithelia of the human body-namely the skin, the intestine and the lung-
have found valid applications in both research and industrial settings as attractive …