This review provides a detailed overview of the rapidly advancing field of biofabrication,
particularly with regards to the use of photo-cross-linking (ie, light-based) techniques. The …

Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

Background Conventional preclinical models often miss drug toxicities, meaning the harm
these drugs pose to humans is only realized in clinical trials or when they make it to market …

The first microfluidic microphysiological systems (MPS) entered the academic scene more
than 15 years ago and were considered an enabling technology to human in vitro (patho) …

Hepatology and drug development for liver diseases require in vitro liver models. Typical
models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte …

We report the development, automation and validation of a 3D, microfluidic liver-on-a-chip
for high throughput hepatotoxicity screening, the OrganoPlate LiverTox™. The model is …

Intestinal epithelial cells are constantly exposed to pathogens and mechanical forces.
However, the impact of mechanical forces on infections leading to diarrheal diseases …

Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …

The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

The human microbiome orchestrates a variety of metabolic, immunological and regulatory
functions in health and disease. However, experimentally dissecting host–microbiome …