Recent years have witnessed tremendous progress in our structural and biophysical
understanding of how replication protein A (RPA), a major nuclear ssDNA-binding protein …

New antibiotics with novel modes of action are required to combat the growing threat posed
by multi-drug resistant bacteria. Over the last decade, genome sequencing and other high …

Single-stranded DNA-binding proteins (SSBs) are required for repair, recombination and
replication in all organisms. Eukaryotic SSBs are regulated by phosphorylation on serine …

The advent of new technologies allowing the study of single biological molecules continues
to have a major impact on studies of interacting systems as well as enzyme reactions. These …

Our understanding of Mycobacterium tuberculosis DNA repair mechanisms is still poor
compared with that of other bacterial organisms. However, the publication of the first …

Single-stranded DNA-binding proteins (SSBs) play vital roles in DNA metabolism. Proteins
of the SSB family exclusively and transiently bind to ssDNA, preventing the DNA double …

Single-stranded DNA (ssDNA)-binding (SSB) proteins are uniformly required to bind and
protect single-stranded intermediates in DNA metabolic pathways. All bacterial and …

The genomic integrity of Mycobacterium tuberculosis is continuously threatened by the
harsh survival conditions inside host macrophages, due to immune and antibiotic stresses …

When replication forks encounter template lesions, one result is lesion skip**, where the
stalled DNA polymerase transiently stalls, disengages, and then reinitiates downstream to …

Bacteria encode homooligomeric single-stranded (ss) DNA-binding proteins (SSBs) that
coat and protect ssDNA intermediates formed during genome maintenance reactions. The …