The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

We review the morphofunctional characteristics of pericytes and report our observations.
After a brief historical background, we consider the following aspects of pericytes: A) Origin …

Bioprinting is rapidly being adopted as a major method for fabricating tissue engineering
constructs. Through the precise deposition of cell-and bioactive molecule-laden materials …

Cancer invasion is a cell-and tissue-driven process for which the physical, cellular, and
molecular determinants adapt and react throughout the progression of the disease. Cancer …

Cell migration is central to a multitude of physiological processes, including embryonic
development, immune surveillance, and wound healing, and deregulated migration is key to …

Stimuli that promote cell migration, such as chemokines, cytokines, and growth factors in
metazoans and cyclic AMP in Dictyostelium, activate signaling pathways that control …

Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …

This protocol describes a simple but robust microfluidic assay combining three-dimensional
(3D) and two-dimensional (2D) cell culture. The microfluidic platform comprises hydrogel …

Cell migration is a complex and heterogeneous process executed by all nucleated cell types
at a given time window of their development. For most cells, including epithelial, stromal …