Acute chest syndrome (ACS) is a frequent cause of acute lung disease in children with sickle
cell disease (SCD). Patients may present with ACS or may develop this complication during …

Sickle cell disease (SCD) is a complex, clinically heterogeneous disorder affecting
approximately 100,000 individuals in the United States and millions worldwide. The disease …

Sex-steroid signaling, especially estrogen, has a paradoxical impact on regulating airway
remodeling. In our previous studies, we demonstrated differential effects of 17β-estradiol (E …

Rationale: Sickle cell disease (SCD) results in significant morbidity and mortality attributable
to pulmonary complications. The pattern of lung function change across childhood in SCD is …

Asthma is a common comorbidity in sickle cell disease (SCD) with a reported prevalence of
30–70%. The high frequency of asthma in this population cannot be attributed to genetic …

The aim of this study was to assess the impact of recurrent acute chest syndrome (ACS)
episodes on the lung function of young adults with sickle cell disease (SCD). Our …

Obstructive and restrictive pulmonary changes develop in children with sickle cell disease,
but reports conflict as to the type of change that predominates. We prospectively performed …

To address the global burden of sickle cell disease and the need for novel therapies, the
American Society of Hematology partnered with the US Food and Drug Administration to …

A physician diagnosis of asthma in children and adults with sickle cell disease (SCD) has
been associated with increased rates of pain and acute chest syndrome (ACS) episodes …

To assess the associations between a doctor diagnosis of asthma and wheezing
(independent of a diagnosis of asthma) with sickle cell disease (SCD) morbidity, we …