Morphological basis of Parkinson disease-associated cognitive impairment: an update

KA Jellinger - Journal of Neural Transmission, 2022 - Springer
Cognitive impairment is one of the most salient non-motor symptoms of Parkinson disease
(PD) that poses a significant burden on the patients and carers as well as being a risk factor …

[HTML][HTML] Pathobiology of cognitive impairment in Parkinson disease: challenges and outlooks

KA Jellinger - International Journal of Molecular Sciences, 2023 - mdpi.com
Cognitive impairment (CI) is a characteristic non-motor feature of Parkinson disease (PD)
that poses a severe burden on the patients and caregivers, yet relatively little is known about …

α-Synuclein is the major platelet isoform but is dispensable for activation, secretion, and thrombosis

AN Smith, S Joshi, H Chanzu, HR Alfar… - Platelets, 2023 - Taylor & Francis
Platelets play many roles in the vasculature ensuring proper hemostasis and maintaining
integrity. These roles are facilitated, in part, by cargo molecules released from platelet …

Effects of white matter hyperintensity on cognitive function in PD patients: a meta-analysis

W Zhao, B Cheng, T Zhu, Y Cui, Y Shen, X Fu… - Frontiers in …, 2023 - frontiersin.org
Background Parkinson's disease (PD) is often accompanied by cognitive dysfunction, which
imposes a heavy burden on patients, their families, and society. Early identification and …

Abnormal circadian blood pressure regulation and cognitive impairment in α-synucleinopathies

R Tanaka, N Hattori - Hypertension Research, 2022 - nature.com
Circadian blood pressure (BP) rhythm is important for the maintenance of healthy daily life,
and its disruption is associated with poor outcomes. Cardiovascular autonomic failure is …

Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson's disease

HH Tsai, LK Tsai, YL Lo, CH Lin - Scientific Reports, 2021 - nature.com
Cerebral microbleeds (MBs) have been found in patients with cognitive decline. We aimed
to examine whether MBs are associated with motor or cognitive decline in patients with …

An interpretable multiparametric radiomics model of basal ganglia to predict dementia conversion in Parkinson's disease

CJ Park, J Eom, KS Park, YW Park, SJ Chung… - npj Parkinson's …, 2023 - nature.com
Cognitive impairment in Parkinson's disease (PD) severely affects patients' prognosis, and
early detection of patients at high risk of dementia conversion is important for establishing …

The influence of white matter hyperintensity on cognitive impairment in Parkinson's disease

H Liu, B Deng, F **e, X Yang, Z **e… - Annals of Clinical …, 2021 - Wiley Online Library
The aim of this meta‐analysis was to review systematically and to identify the relationship
between the severity and location of white matter hyperintensities (WMHs) and the degree of …

A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease

D Loureiro, R Bilbao, S Bordet, L Grasso… - Neurological …, 2023 - Springer
Background Cognitive impairment is a frequent disabling feature of Parkinson's disease
(PD). Orthostatic hypotension (OH) is treatable and may be a risk factor for cognitive …

Is White Matter Hyperintensity Burden Associated with Cognitive and Motor Impairment in Patients with Parkinson's Disease? A Systematic Review and Meta-Analysis

DCC de Abreu, F Pieruccini-Faria, S Son… - Neuroscience & …, 2024 - Elsevier
White matter damage quantified as white matter hyperintensities (WMH) may aggravate
cognitive and motor impairments, but whether and how WMH burden impacts these …