Targeting adenosine in cancer immunotherapy to enhance T-cell function
S Vigano, D Alatzoglou, M Irving… - Frontiers in …, 2019 - frontiersin.org
T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …
Adenosine and inflammation: here, there and everywhere
Adenosine is a ubiquitous endogenous modulator with the main function of maintaining
cellular and tissue homeostasis in pathological and stress conditions. It exerts its effect …
cellular and tissue homeostasis in pathological and stress conditions. It exerts its effect …
Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression
Y Watanabe, T Fukuda, C Hayashi, Y Nakao… - Scientific reports, 2022 - nature.com
Immunoregulatory properties of mesenchymal stem cell (MSC)-derived extracellular vesicles
(EVs) are promising. Gingival tissue-derived MSCs (GMSCs) have unique …
(EVs) are promising. Gingival tissue-derived MSCs (GMSCs) have unique …
Purinergic signaling in the hallmarks of cancer
AR Campos-Contreras, M Díaz-Muñoz… - Cells, 2020 - mdpi.com
Cancer is a complex expression of an altered state of cellular differentiation associated with
severe clinical repercussions. The effort to characterize this pathological entity to understand …
severe clinical repercussions. The effort to characterize this pathological entity to understand …
EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis
Aberrant activation of EGFR in human cancers promotes tumorigenesis through stimulation
of AKT signaling. Here, we determined that the discoidina neuropilin-like membrane protein …
of AKT signaling. Here, we determined that the discoidina neuropilin-like membrane protein …
Controlling the immune suppressor: transcription factors and microRNAs regulating CD73/NT5E
T Kordaß, W Osen, SB Eichmüller - Frontiers in immunology, 2018 - frontiersin.org
The NT5E (CD73) molecule represents an ecto-5′-nucleotidase expressed on the cell
surface of various cell types. Hydrolyzing extracellular adenosine monophosphate into …
surface of various cell types. Hydrolyzing extracellular adenosine monophosphate into …
Immune escape mechanisms in colorectal cancer pathogenesis and liver metastasis
M Pancione, G Giordano, A Remo… - Journal of …, 2014 - Wiley Online Library
Over the past decade, growing evidence indicates that the tumor microenvironment (TME)
contributes with genomic/epigenomic aberrations of malignant cells to enhance cancer cells …
contributes with genomic/epigenomic aberrations of malignant cells to enhance cancer cells …
Pancreatic cancer survival analysis defines a signature that predicts outcome
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the
US. Despite multiple large-scale genetic sequencing studies, identification of predictors of …
US. Despite multiple large-scale genetic sequencing studies, identification of predictors of …
CD73 induces gemcitabine resistance in pancreatic ductal adenocarcinoma: A promising target with non-canonical mechanisms
CD73, a cell surface-localized ecto-5′-nucleotidase, is the major enzymatic source of
extracellular adenosine. Canonically, it plays multiple roles in cancer-related processes via …
extracellular adenosine. Canonically, it plays multiple roles in cancer-related processes via …
Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in …
G Giordano, A Febbraro, E Tomaselli… - Journal of experimental …, 2015 - Springer
Background Cancer-related immune antigens in the tumor microenvironment could
represent an obstacle to agents targeting EGFR “cetuximab” or VEGF “bevacizumab” in …
represent an obstacle to agents targeting EGFR “cetuximab” or VEGF “bevacizumab” in …