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Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics
HR **, J Wang, ZJ Wang, MJ **, BH **a… - Journal of hematology & …, 2023 - Springer
Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …
The role of lipids in cancer progression and metastasis
Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …
as a signaling molecule, and being a structural component of membranes); however, an …
Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective
Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …
Lipid metabolism and cancer
Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …
Tumour fatty acid metabolism in the context of therapy resistance and obesity
Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …
Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer
Hypercholesterolemia and dyslipidemia are associated with an increased risk for many
cancer types and with poor outcomes in patients with established disease. Whereas the …
cancer types and with poor outcomes in patients with established disease. Whereas the …
Drug-tolerant persister cells in cancer: the cutting edges and future directions
Drug-tolerant persister (DTP) cell populations were originally discovered in antibiotic-
resistant bacterial biofilms. Similar populations with comparable features have since been …
resistant bacterial biofilms. Similar populations with comparable features have since been …
Targeting MAPK signaling in cancer: mechanisms of drug resistance and sensitivity
Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …
[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate
CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and
non-immune cells. It functions as both a signaling receptor responding to DAMPs and …
non-immune cells. It functions as both a signaling receptor responding to DAMPs and …