A growing body of evidence suggests that mechanical signals emanating from the cell's
microenvironment are fundamental regulators of cell behaviour. Moreover, at the …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …

Directional cell migration normally relies on a variety of external signals, such as chemical,
mechanical, or electrical, which instruct cells in which direction to move. Many of the major …

Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …

Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

Tissue injury disrupts the mechanical homeostasis that underlies normal tissue architecture
and function. The failure to resolve injury and restore homeostasis gives rise to progressive …

Fibrosis is a central pathway that drives progression of multiple chronic diseases, yet few
safe and effective clinical antifibrotic therapies exist. In most fibrotic disorders, transforming …

Tissue fibrosis is characterized by uncontrolled deposition and diminished clearance of
fibrous connective tissue proteins, ultimately leading to organ scarring. Yes-associated …