The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Transient receptor potential (TRP) channels are one primary type of calcium (Ca 2+)
permeable channels, and those relevant transmembrane and intracellular TRP channels …

Endothelial dysfunction is a major player in the development and progression of vascular
pathology in pulmonary arterial hypertension (PAH), a disease associated with small vessel …

The vascular endothelium is a broadly distributed and highly specialized organ. The
endothelium has a number of functions including the control of blood vessels diameter …

A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and forms a
multifunctional transducing organ that mediates a plethora of cardiovascular processes. The …

Transient receptor potential canonical (TRPC) proteins assemble to form homo-or
heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC …

The primary purpose of this review is to address the progress towards small molecule
modulators of human T ransient R eceptor P otential C anonical proteins (TRPC1, TRPC3 …

Transient receptor potential ankyrin repeat 1 (TRPA1) forms calcium (Ca 2+)-and zinc (Zn
2+)-permeable ion channels that sense noxious substances. Despite the biological and …