The principles of directed cell migration

S SenGupta, CA Parent, JE Bear - Nature Reviews Molecular Cell …, 2021 - nature.com
Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

Modulation of immune responses by particle size and shape

MV Baranov, M Kumar, S Sacanna… - Frontiers in …, 2021 - frontiersin.org
The immune system has to cope with a wide range of irregularly shaped pathogens that can
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …

Topography-mediated immunomodulation in osseointegration; Ally or Enemy

S Shirazi, S Ravindran, LF Cooper - Biomaterials, 2022 - Elsevier
Osteoimmunology is at full display during endosseous implant osseointegration. Bone
formation, maintenance and resorption at the implant surface is a result of bidirectional and …

High‐aspect‐ratio nanostructured surfaces as biological metamaterials

SG Higgins, M Becce… - Advanced …, 2020 - Wiley Online Library
Materials patterned with high‐aspect‐ratio nanostructures have features on similar length
scales to cellular components. These surfaces are an extreme topography on the cellular …

Tutorial: using nanoneedles for intracellular delivery

C Chiappini, Y Chen, S Aslanoglou, A Mariano… - Nature …, 2021 - nature.com
Intracellular delivery of advanced therapeutics, including biologicals and supramolecular
agents, is complex because of the natural biological barriers that have evolved to protect the …

The plasma membrane as a mechanochemical transducer

AL Le Roux, X Quiroga, N Walani… - … of the Royal …, 2019 - royalsocietypublishing.org
Cells are constantly submitted to external mechanical stresses, which they must withstand
and respond to. By forming a physical boundary between cells and their environment that is …

Enzymatic assemblies disrupt the membrane and target endoplasmic reticulum for selective cancer cell death

Z Feng, H Wang, S Wang, Q Zhang… - Journal of the …, 2018 - ACS Publications
The endoplasmic reticulum (ER) is responsible for the synthesis and folding of a large
number of proteins, as well as intracellular calcium regulation, lipid synthesis, and lipid …

Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording

Y Zhao, SS You, A Zhang, JH Lee, J Huang… - Nature …, 2019 - nature.com
New tools for intracellular electrophysiology that push the limits of spatiotemporal resolution
while reducing invasiveness could provide a deeper understanding of electrogenic cells and …

Cellular and subcellular contact guidance on microfabricated substrates

C Leclech, C Villard - Frontiers in bioengineering and biotechnology, 2020 - frontiersin.org
Topography of the extracellular environment is now recognized as a major biophysical
regulator of cell behavior and function. The study of the influence of patterned substrates on …

Dissecting biological and synthetic soft–hard interfaces for tissue-like systems

Y Fang, X Yang, Y Lin, J Shi, A Prominski… - Chemical …, 2021 - ACS Publications
Soft and hard materials at interfaces exhibit mismatched behaviors, such as mismatched
chemical or biochemical reactivity, mechanical response, and environmental adaptability …