Innate and acquired chemoresistance exhibited by most tumours exposed to conventional
chemotherapeutic agents account for the majority of relapse cases in cancer patients. Such …

Multidrug resistance‐associated protein 1 (MRP1, ABCC1) is an ATP‐binding cassette
(ABC) transport protein. This efflux pump uses the energy of ATP hydrolysis to export …

Several ABC transporters (eg, ABCB1, ABCB4, ABCC1–5, ABCC10, ABCG2 and ABCG4)
are known to contribute to the phenomenon of cancer-related multidrug resistance (MDR)[1] …

Alzheimer's disease (AD) is a devastating neurological disorder characterized by the
pathological accumulation of macromolecular Aβ and tau leading to neuronal death. Drugs …

P-Glycoprotein (P-gp, ABCB1), multidrug resistance-associated protein 1 (MRP1, ABCC1),
and breast cancer resistance protein (BCRP, ABCG2) are the three major ABC transport …

Based on literature reports of the last two decades, a computer-aided pattern analysis (C@
PA) was implemented for the discovery of novel multitarget ABCB1 (P-gp), ABCC1 (MRP1) …

Abstract Multidrug resistance protein 1 (MRP1/ABCC1) is an ATP-dependent efflux
transporter, and responsible for the transport of a broad spectrum of xenobiotics, toxins, and …

Abstract Adenosine-triphosphate-(ATP)-binding cassette (ABC) transport proteins are
ubiquitously present membrane-bound efflux pumps that distribute endo-and xenobiotics …

Recent studies hint that Ginsenoside is involved in cancer prevention and treatment. In this
study, we investigated the effect of Ginsenoside Rh2 on drug resistance in human colorectal …

During cancer chemotherapy, certain cancers may become cross-resistant to structurally
diverse antineoplastic agents. This so-called multidrug resistance (MDR) is highly …