Bacterial infections, caused predominately by Gram-positive and Gram-negative organisms,
are proliferation of harmful strains of bacteria on or inside the body. Hospital-acquired and …

β-Lactamases, the enzymes that hydrolyze β-lactam antibiotics, remain the greatest threat to
the usage of these agents. In this review, the mechanism of hydrolysis is discussed for both …

Antibiotic resistance caused by β-lactamase production continues to present a growing
challenge to the efficacy of β-lactams and their role as the most important class of clinically …

There is urgent need for new therapeutic strategies to fight the global threat of antibiotic
resistance. The focus of this Perspective is on chemical agents that target the most common …

Identifying drug–target interactions (DTIs) is important for drug discovery. However,
searching all drug–target spaces poses a major bottleneck. Therefore, recently many deep …

The emergence of Klebsiella pneumoniae carbapenemases (KPCs), β-lactamases that
inactivate “last-line” antibiotics such as imipenem, represents a major challenge to …

The effectiveness of β-lactam antibiotics is increasingly influenced by serine β-lactamases
(SBLs) and metallo-β-lactamases (MBLs), which can hydrolyze β-lactam antibiotics. The …

Thiophene, as a member of the group of five‐membered heterocycles containing one
heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the …

The most common mechanism of resistance to β-lactams antibiotics in Gram-negative
bacteria is production of β-lactamase enzymes capable of cleaving the β-lactam ring …

The emergence and spread of bacterial pathogens acquired metallo-β-lactamase (MBL) and
serine-β-lactamase (SBL) medicated β-lactam resistance gives rise to an urgent need for the …