[HTML][HTML] Myelin in the central nervous system: structure, function, and pathology
C Stadelmann, S Timmler… - Physiological …, 2019 - journals.physiology.org
Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …
The role of glial cells in multiple sclerosis disease progression
Despite the development of highly effective treatments for relapsing–remitting multiple
sclerosis (MS), limited progress has been made in addressing primary progressive or …
sclerosis (MS), limited progress has been made in addressing primary progressive or …
Complement in neurological disorders and emerging complement-targeted therapeutics
The complement system consists of a network of plasma and membrane proteins that
modulate tissue homeostasis and contribute to immune surveillance by interacting with the …
modulate tissue homeostasis and contribute to immune surveillance by interacting with the …
Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease
JF Ghersi-Egea, N Strazielle, M Catala… - Acta …, 2018 - Springer
The barrier between the blood and the ventricular cerebrospinal fluid (CSF) is located at the
choroid plexuses. At the interface between two circulating fluids, these richly vascularized …
choroid plexuses. At the interface between two circulating fluids, these richly vascularized …
Choroid plexus enlargement in inflammatory multiple sclerosis: 3.0-T MRI and translocator protein PET evaluation
Background Choroid plexuses (CPs) have been suggested as a key gateway for
inflammation in experimental autoimmune encephalitis, but in vivo evidence of their …
inflammation in experimental autoimmune encephalitis, but in vivo evidence of their …
Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans
Neuroinflammation is a pathophysiological hallmark of multiple sclerosis and has a close
mechanistic link to neurodegeneration. Although this link is potentially targetable, robust …
mechanistic link to neurodegeneration. Although this link is potentially targetable, robust …
Hope for patients with neuromyelitis optica spectrum disorders—from mechanisms to trials
SJ Pittock, A Zekeridou, BG Weinshenker - Nature Reviews Neurology, 2021 - nature.com
Neuromyelitis optica spectrum disorder (NMOSD) is a rare inflammatory CNS disease that
primarily manifests as relapsing episodes of severe optic neuritis and myelitis. Diagnosis of …
primarily manifests as relapsing episodes of severe optic neuritis and myelitis. Diagnosis of …
Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion
Neuromyelitis optica (NMO) is a severe inflammatory autoimmune CNS disorder triggered
by binding of an IgG autoantibody to the aquaporin 4 (AQP4) water channel on astrocytes …
by binding of an IgG autoantibody to the aquaporin 4 (AQP4) water channel on astrocytes …
The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes
Background Elevated production of the cytokines interleukin (IL)-6 or interferon (IFN)-α in the
central nervous system (CNS) is implicated in the pathogenesis of neurological diseases …
central nervous system (CNS) is implicated in the pathogenesis of neurological diseases …
Vascular pathology in multiple sclerosis: reframing pathogenesis around the blood-brain barrier
JI Spencer, JS Bell, GC DeLuca - Journal of Neurology, Neurosurgery …, 2018 - jnnp.bmj.com
Blood-brain barrier (BBB) disruption has long been recognised as an important early feature
of multiple sclerosis (MS) pathology. Traditionally, this has been seen as a by-product of the …
of multiple sclerosis (MS) pathology. Traditionally, this has been seen as a by-product of the …