Clinical diagnosis of gastrointestinal stromal tumor (GIST): from the molecular genetic point of view
Gastrointestinal stromal tumors (GISTs) originating from the interstitial cells of Cajal are
mesenchymal tumors of the gastrointestinal tract and have been found to harbor c-KIT …
mesenchymal tumors of the gastrointestinal tract and have been found to harbor c-KIT …
[HTML][HTML] The role of mitochondrial dynamics in human cancers
Y Ma, L Wang, R Jia - American journal of cancer research, 2020 - ncbi.nlm.nih.gov
Mitochondria are crucial cellular organelles. Under extracellular stimulations, mitochondria
undergo constant fusion and fission dynamics to meet different cellular demands …
undergo constant fusion and fission dynamics to meet different cellular demands …
Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop
J Wang, Q Lu, J Cai, Y Wang, X Lai, Y Qiu… - Nature …, 2019 - nature.com
Abnormal cancer antioxidant capacity is considered as a potential mechanism of tumor
malignancy. Modulation of oxidative stress status is emerging as an anti-cancer treatment …
malignancy. Modulation of oxidative stress status is emerging as an anti-cancer treatment …
A neuronal network of mitochondrial dynamics regulates metastasis
The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we
now show that tumours reprogram a network of mitochondrial dynamics operative in …
now show that tumours reprogram a network of mitochondrial dynamics operative in …
[HTML][HTML] Targeted homing of CCR2-overexpressing mesenchymal stromal cells to ischemic brain enhances post-stroke recovery partially through PRDX4-mediated …
Y Huang, J Wang, J Cai, Y Qiu, H Zheng, X Lai… - Theranostics, 2018 - ncbi.nlm.nih.gov
Abstract Rationale: Mesenchymal stromal cells (MSCs) are emerging as a novel therapeutic
strategy for the acute ischemic stroke (AIS). However, the poor targeted migration and low …
strategy for the acute ischemic stroke (AIS). However, the poor targeted migration and low …
[HTML][HTML] Distribution, contribution and regulation of nestin+ cells
Background Nestin is an intermediate filament first reported in neuroepithelial stem cells.
Nestin expression could be found in a variety of tissues throughout all systems of the body …
Nestin expression could be found in a variety of tissues throughout all systems of the body …
Nestin promotes pulmonary fibrosis via facilitating recycling of TGF-β receptor I
J Wang, X Lai, S Yao, H Chen, J Cai… - European …, 2022 - Eur Respiratory Soc
Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease that is
characterised by aberrant proliferation of activated myofibroblasts and pathological …
characterised by aberrant proliferation of activated myofibroblasts and pathological …
Nestin-dependent mitochondria-ER contacts define stem Leydig cell differentiation to attenuate male reproductive ageing
S Yao, X Wei, W Deng, B Wang, J Cai, Y Huang… - Nature …, 2022 - nature.com
Male reproductive system ageing is closely associated with deficiency in testosterone
production due to loss of functional Leydig cells, which are differentiated from stem Leydig …
production due to loss of functional Leydig cells, which are differentiated from stem Leydig …
Nestin protects podocyte from injury in lupus nephritis by mitophagy and oxidative stress
Y Tian, H Guo, X Miao, J Xu, R Yang, L Zhao, J Liu… - Cell death & …, 2020 - nature.com
Podocyte injury is the main cause of proteinuria in lupus nephritis (LN). Nestin, an important
cytoskeleton protein, is expressed stably in podocytes and is associated with podocyte …
cytoskeleton protein, is expressed stably in podocytes and is associated with podocyte …
Mitochondrial dynamics in type 2 diabetes and cancer
Mitochondria are bioenergetic, biosynthetic, and signaling organelles that control various
aspects of cellular and organism homeostasis. Quality control mechanisms are in place to …
aspects of cellular and organism homeostasis. Quality control mechanisms are in place to …