I review single-molecule experiments (SMEs) in biological physics. Recent technological
developments have provided the tools to design and build scientific instruments of high …

From the extracellular matrix to the cytoskeleton, a network of molecular links connects cells
to their environment. Molecules in this network transmit and detect mechanical forces, which …

Long residence times of soil organic matter have been attributed to reactive mineral surface
sites that sorb organic species and cause inaccessibility due to physical isolation and …

Single molecule force spectroscopy probes the strength, lifetime, and energetic details of
intermolecular interactions in a simple experiment. A growing number of these studies have …

Traditional monoclonal antibodies such as Trastuzumab encounter limitations when treating
Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer, particularly in …

Single-molecule force spectroscopy with the atomic force microscope provides molecular
level insights into protein function, allowing researchers to reconstruct energy landscapes …

We report a fluorescence-based turn-on sensor for map** the mechanical strain exerted
by specific cell-surface proteins in living cells. The sensor generates force maps with high …

Mechanical forces are central to most, if not all, biological processes, including cell
development, immune recognition, and metastasis. Because the cellular machinery …

Minor group human rhinoviruses (HRVs) attach to members of the low-density lipoprotein
receptor family and are internalized via receptor-mediated endocytosis. The attachment of …

Atomic force spectroscopy (AFS) is one of the most promising and powerful tools to get
information on biorecognition processes at single molecule resolution. AFS allows to …