Simple Summary Loss of SMARCB1 has been identified as the sole mutation in a number of
rare pediatric and adult cancers, most of which have a poor prognosis despite intensive …

Precision oncology is an innovative approach to cancer care in which diagnosis, prognosis,
and treatment are informed by the individual patient's genetic and molecular profile. The …

Atypical teratoid rhabdoid tumors (AT/RT) are malignant central nervous system (CNS)
tumors that occur mostly in young children and have historically carried a very poor …

Atypical teratoid/rhabdoid tumors (AT/RT) are the most common malignant brain tumors
manifesting in infancy. They split into four molecular types. The major three (AT/RT-SHH …

Methylation profiling has radically transformed our understanding of tumors previously
called central nervous system primitive neuro-ectodermal tumors (CNS-PNET). While this …

Atypical teratoid/rhabdoid tumors (ATRTs) represent a rare, but aggressive pediatric brain
tumor entity. They are genetically defined by alterations in the SWI/SNF chromatin …

Purpose: To assess the main imaging and clinical features in adult-and pediatric-onset
atypical teratoid rhabdoid tumor (ATRT) in order to build a predefined pathway useful for the …

Tumors of the central nervous system (CNS) are a leading cause of morbidity and mortality
in the pediatric population. Molecular characterization in the last decade has redefined CNS …

Background Recurrent atypical teratoid/rhabdoid tumor (AT/RT) is, most often, a fatal
pediatric malignancy with limited curative options. Methods We conducted a phase II study …

Atypical teratoid/rhabdoid tumors (ATRT) are malignant embryonal tumors, most often
presenting in children under three years of age [7]. Three consensus ATRT molecular …