Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's disease (AD). It is characterized by a progressive loss of dopaminergic neurons …

Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In
the past decade, development of the new magnetic resonance imaging technique …

The brain tissue phase contrast in MRI sequences reflects the spatial distributions of multiple
substances, such as iron, myelin, calcium, and proteins. These substances with …

Purpose A method named DECOMPOSE-QSM is developed to decompose bulk
susceptibility measured with QSM into sub-voxel paramagnetic and diamagnetic …

Abstract Background Patients with Parkinson's disease (PD) have elevated levels of brain
iron, especially in the nigrostriatal dopaminergic system. The purpose of this study was to …

Diffusion tensor imaging (DTI) allows measuring fractional anisotropy and similar
microstructural indices of the brain white matter. Lower than normal fractional anisotropy as …

Quantitative susceptibility map** (QSM) has gained broad interest in the field by extracting
bulk tissue magnetic susceptibility, predominantly determined by myelin, iron and calcium …

To separate the contributions of paramagnetic and diamagnetic sources within a voxel, a
magnetic susceptibility source separation method based solely on gradient-echo data has …

Background Previous studies have shown that magnetic susceptibility is increased in
several subcortical regions in progressive supranuclear palsy (PSP). However, it is still …

Parkinson's disease (PD) is a common neurodegenerative disorder. It has a delitescent
onset and a slow progress. The clinical manifestations of PD in patients are highly …