Abstract Cardiac digital twins (Cardiac Digital Twin (CDT) s) of human electrophysiology
(Electrophysiology (EP)) are digital replicas of patient hearts derived from clinical data that …

Mathematical models of the human heart are evolving to become a cornerstone of precision
medicine and support clinical decision making by providing a powerful tool to understand …

Computer modeling of the electrophysiology of the heart has undergone significant
progress. A healthy heart can be modeled starting from the ion channels via the spread of a …

The Purkinje network is an integral part of the excitation system in the human heart. Yet, to
date, there is no in vivo imaging technique to accurately reconstruct its geometry and …

During the contraction of the ventricles, the ventricles interact with the atria as well as with
the pericardium and the surrounding tissue in which the heart is embedded. The atria are …

This paper examined the effects that different tissue conductivities had on forward-calculated
ECGs. To this end, we ranked the influence of tissues by performing repetitive forward …

Heart failure with preserved ejection fraction (HFpEF) accounts for about 50% of heart failure
cases. It has features of incomplete relaxation and increased stiffness of the left ventricle …

Despite the commonly accepted notion that action potential duration (APD) is distributed
heterogeneously throughout the ventricles and that the associated dispersion of …

The short QT syndrome (SQTS) is a genetically heterogeneous condition characterized by
abbreviated QT intervals and an increased susceptibility to arrhythmia and sudden death …

A mutation to serine of a conserved threonine (T634S) in the hERG K+ channel S6 pore
region has been identified as a variant of uncertain significance, showing a loss-of-function …