The emergence of drug resistance is a major challenge for oncologists. Resistance can be
categorized as acquired or intrinsic; the alteration of several biological mechanisms …

It is clear now that proteins lacking ordered structure, generally known as intrinsically
disordered proteins (IDPs), possess numerous biological functions that complement …

Peptide–protein interactions are among the most prevalent and important interactions in the
cell, but a large fraction of those interactions lack detailed structural characterization. The …

A wide range of regulatory processes in the cell are mediated by flexible peptides that fold
upon binding to globular proteins. Computational efforts to model these interactions are …

Interactions between short modified peptide motifs and modular protein domains are central
events in cell signal‐transduction. We determined interaction partners to all cytosolic …

One particularly abundant group of modular recognition domains consists of those that bind
proline-rich motifs. Such modules, including the SH3, WW, and EVH1 domains, play a …

The phytochromes are a family of plant photoreceptor proteins that control several adaptive
developmental strategies,. For example, the phytochromes perceive far-red light …

Most proteins that participate in cellular signalling networks contain modular protein-
interaction domains. Multiple versions of such domains are present within a given organism …

SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of
protein complexes through physical interactions with a pool of proline-rich/noncanonical …

Regulated interactions between short, unstructured amino acid sequences and modular
protein domains are central to cell signaling. Here we use synthetic peptides in" active"(eg …