The pathophysiology of gestational diabetes mellitus

JF Plows, JL Stanley, PN Baker, CM Reynolds… - International journal of …, 2018 - mdpi.com
Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women
without previously diagnosed diabetes develop chronic hyperglycemia during gestation. In …

Pathophysiology from preconception, during pregnancy, and beyond

MF Hivert, H Backman, K Benhalima, P Catalano… - The Lancet, 2024 - thelancet.com
Gestational diabetes is the most common medical complication in pregnancy. Historically,
gestational diabetes was considered a pregnancy complication involving treatment of rising …

The placenta as a mediator of stress effects on neurodevelopmental reprogramming

SL Bronson, TL Bale - Neuropsychopharmacology, 2016 - nature.com
Adversity experienced during gestation is a predictor of lifetime neuropsychiatric disease
susceptibility. Specifically, maternal stress during pregnancy predisposes offspring to sex …

[PDF][PDF] The human placenta in gestational diabetes mellitus: the insulin and cytokine network

G Desoye, S Hauguel-de Mouzon - Diabetes care, 2007 - mundialsiglo21.com
The placenta is a complex fetal organ that fulfills pleiotropic roles during fetal growth. It
separates the maternal and fetal circulation, with which it is in contact through different …

Immunoendocrine dysregulation during gestational diabetes mellitus: The central role of the placenta

A Olmos-Ortiz, P Flores-Espinosa, L Díaz… - International Journal of …, 2021 - mdpi.com
Gestational Diabetes Mellitus (GDM) is a transitory metabolic condition caused by
dysregulation triggered by intolerance to carbohydrates, dysfunction of beta-pancreatic and …

[HTML][HTML] Consequences of gestational and pregestational diabetes on placental function and birth weight

A Vambergue, I Fajardy - World journal of diabetes, 2011 - ncbi.nlm.nih.gov
Maternal diabetes constitutes an unfavorable environment for embryonic and fetoplacental
development. Despite current treatments, pregnant women with pregestational diabetes are …

Insulin and the IGF system in the human placenta of normal and diabetic pregnancies

U Hiden, E Glitzner, M Hartmann… - Journal of anatomy, 2009 - Wiley Online Library
The insulin/insulin‐like growth factor (IGF) system regulates fetal and placental growth and
development. In maternal diabetes, components of this system including insulin, IGF1, IGF2 …

[HTML][HTML] The elusive role of placental macrophages: the Hofbauer cell

MZ Zulu, FO Martinez, S Gordon, CM Gray - Journal of innate immunity, 2019 - karger.com
In this review, we discuss the often overlooked tissue-resident fetal macrophages, Hofbauer
cells, which are found within the chorionic villi of the human placenta. Hofbauer cells have …

Human placental Hofbauer cells maintain an anti-inflammatory M2 phenotype despite the presence of gestational diabetes mellitus

C Schliefsteiner, M Peinhaupt, S Kopp, J Lögl… - Frontiers in …, 2017 - frontiersin.org
Background Hofbauer cells (HBCs) are macrophages of the feto-placental unit. Despite the
general view that these cells have an anti-inflammatory M2 phenotype, recent studies have …

Obesity and pregnancy, the perfect metabolic storm

P Corrales, A Vidal-Puig… - European journal of clinical …, 2021 - nature.com
Pregnancy is a physiological stress that requires dynamic, regulated changes affecting
maternal and fetal adiposity. Excessive accumulation of dysfunctional adipose tissue …