The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Accurate and automated methods for measuring the thickness of human cerebral cortex
could provide powerful tools for diagnosing and studying a variety of neurodegenerative and …

Schizophrenia is a disease of abnormal brain development. Considerable evidence now
indicates that environmental factors have a causative role in schizophrenia. Elevated …

Background The pathophysiological characteristics of schizophrenia appear to involve
altered synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role that …

After more than 100 years of research, the neuropathology of schizophrenia remains
unknown and this is despite the fact that both: Kraepelin, E., 1919/1971. Dementia praecox …

OBJECTIVE: The authors' goal was to determine whether patients with schizophrenia differ
from comparison subjects in regional brain volumes and whether these differences are …

Objective: To model in vivo the dynamic interrelations of head size, gray matter, white matter,
and cerebrospinal fluid (CSF) volumes from infancy to old age using magnetic resonance …

Schizophrenia has historically been considered to be a deteriorating disease, a view
reinforced by recent MRI findings of progressive brain tissue loss over the early years of …

Dendrite morphogenesis is a complex but well-orchestrated process and includes the
development of dendritic branches, forming characteristic dendrite arbors, and dendritic …