[HTML][HTML] Possible mechanisms of lymphopenia in severe tuberculosis

F Li, D Chen, Q Zeng, Y Du - Microorganisms, 2023 - mdpi.com
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M.
tuberculosis). In lymphopenia, T cells are typically characterized by progressive loss and a …

The emerging role of myeloid-derived suppressor cells in tuberculosis

T Magcwebeba, A Dorhoi, N du Plessis - Frontiers in immunology, 2019 - frontiersin.org
Myeloid cells are crucial for the host control of a Mycobacterium tuberculosis (M. tb)
infection, however the adverse role of specific myeloid subsets has increasingly been …

Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus

A Dorhoi, LA Kotzé, JA Berzofsky, Y Sui… - The Journal of clinical …, 2020 - jci.org
The critical role of suppressive myeloid cells in immune regulation has come to the forefront
in cancer research, with myeloid-derived suppressor cells (MDSCs) as a main oncology …

Mycobacterium tuberculosis exploits MPT64 to generate myeloid-derived suppressor cells to evade the immune system

S Singh, SK Maurya, M Aqdas, H Bashir… - Cellular and molecular …, 2022 - Springer
Mycobacterium tuberculosis (Mtb) is a smart and successful pathogen since it can persist in
the intimidating environment of the host by taming and tuning the immune system. Mtb …

Establishment of a patient-derived, magnetic levitation-based, three-dimensional spheroid granuloma model for human tuberculosis

LA Kotze, CGG Beltran, D Lang, AG Loxton, S Cooper… - Msphere, 2021 - journals.asm.org
Tuberculous granulomas that develop in response to Mycobacterium tuberculosis (M.
tuberculosis) infection are highly dynamic entities shaped by the host immune response and …

Myeloid-derived suppressor cells mediate T cell dysfunction in nonhuman primate TB granulomas

B Singh, DK Singh, SR Ganatra, RA Escobedo… - Mbio, 2021 - journals.asm.org
Myeloid-derived suppressor cells (MDSCs) represent an innate immune cell population
comprised of immature myeloid cells and myeloid progenitors with very potent …

Mycobacterium tuberculosis and myeloid-derived suppressor cells: Insights into caveolin rich lipid rafts

LA Kotzé, C Young, VN Leukes, V John, Z Fang… - …, 2020 - thelancet.com
Mycobacterium tuberculosis (M. tb) is likely the most successful human pathogen, capable of
evading protective host immune responses and driving metabolic changes to support its …

VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection

S Tyagi, S Sadhu, T Sharma, A Paul… - Frontiers in …, 2024 - frontiersin.org
Mechanistic understanding of antibiotic persistence is a prerequisite in controlling the
emergence of MDR cases in Tuberculosis (TB). We have reported that the cholesterol …

Suppressive myeloid cells in SARS-CoV-2 and Mycobacterium tuberculosis co-infection

JA Shaw, ST Malherbe, G Walzl… - Frontiers in …, 2023 - frontiersin.org
Epidemiologic data show that both current and previous tuberculosis (TB) increase the risk
of in-hospital mortality from coronavirus disease-2019 (COVID-19), and there is a similar …

[HTML][HTML] Immunosuppressive features of the Microenvironment in Lymph Nodes Granulomas from Tuberculosis and HIV–Co-Infected patients

S Ashenafi, JR Muvva, A Mily, J Snäll, M Zewdie… - The American Journal of …, 2022 - Elsevier
Tuberculosis (TB) and HIV co-infection claims many lives every year. This study assessed
immune responses in Mycobacterium tuberculosis–infected lymph node tissues from HIV …