Mass spectrometry is a powerful analytical tool used for the analysis of a wide range of
substances and matrices; it is increasingly utilized for clinical applications in laboratory …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Background Mass spectrometric-based measurements of the steroid metabolome have
been introduced to diagnose disorders featuring abnormal steroidogenesis. Defined …

Liquid chromatography–tandem mass spectrometry (LC–MS/MS) is a powerful tool that is
changing the way we analyse steroids in the clinical laboratory. It is already opening up the …

BACKGROUND Differentiating patients with primary aldosteronism caused by aldosterone-
producing adenomas (APAs) from those with bilateral adrenal hyperplasia (BAH), which is …

Liquid chromatography tandem mass spectrometry (LC-MS/MS) is increasingly becoming
the method of choice for steroid hormone measurements due to small sample volumes, fast …

Alcohol and ketogenic diets increase water consumption. Here, we show that the hormone
FGF21 is required for this drinking response in mice. Circulating levels of FGF21 are …

Bisphenols, parabens, alkylphenols and triclosan are anthropogenic substances with a
phenolic group that have been introduced to the environment in recent decades. As they …

Hypertension is defined as a persistently elevated blood pressure≥ 140/90 mm Hg. It is an
important treatable risk factor for cardiovascular disease, with a high prevalence in the …

Context Current threshold values for primary aldosteronism (PA) diagnostic testing are
based on measuring aldosterone (PAC) using immunoassays. Quantification of PAC by …