Molecular Organization and Regulation of the Mammalian Synapse by the Post-Translational Modification SUMOylation
Neurotransmission occurs within highly specialized compartments forming the active
synapse where the complex organization and dynamics of the interactions are tightly …
synapse where the complex organization and dynamics of the interactions are tightly …
miR-351-5p regulation of CPEB3 affecting aluminium-induced learning and memory impairment in SD rats
J Ji, Y Xu, Y Wang, G Zhang, X Tian, Y Zhang… - Environmental …, 2024 - Elsevier
Aluminium exposure has been found to impair learning and memory abilities; however, the
underlying molecular mechanisms remain unclear. In this study we conducted a double …
underlying molecular mechanisms remain unclear. In this study we conducted a double …
[HTML][HTML] Phase separation modulates the functional amyloid assembly of human CPEB3
DR De Mingo, P López-García, ME Vaquero… - Progress in …, 2023 - Elsevier
How functional amyloids are regulated to restrict their activity is poorly understood. The
cytoplasmic polyadenylation element-binding protein 3 (CPEB3) is an RNA-binding protein …
cytoplasmic polyadenylation element-binding protein 3 (CPEB3) is an RNA-binding protein …
Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory
A self-cleaving ribozyme that maps to an intron of the cytoplasmic polyadenylation element-
binding protein 3 (Cpeb3) gene is thought to play a role in human episodic memory, but the …
binding protein 3 (Cpeb3) gene is thought to play a role in human episodic memory, but the …
Vectorial channeling as a mechanism for translational control by functional prions and condensates
Translation of messenger RNA (mRNA) is regulated through a diverse set of RNA-binding
proteins. A significant fraction of RNA-binding proteins contains prion-like domains which …
proteins. A significant fraction of RNA-binding proteins contains prion-like domains which …
Neuralized1-Mediated CPEB3 Ubiquitination in the Spinal Dorsal Horn Contributes to the Pathogenesis of Neuropathic Pain in Rats
J Zhang, X Zhang, Y Gao, L Li, L Bai… - ACS Chemical …, 2023 - ACS Publications
Compelling evidence has shown that Neuralized1 (Neurl1) facilitates hippocampal-
dependent memory storage by modulating cytoplasmic polyadenylation element-binding …
dependent memory storage by modulating cytoplasmic polyadenylation element-binding …
A structural dynamics model for how CPEB3 binding to SUMO2 can regulate translational control in dendritic spines
A prion-like RNA-binding protein, CPEB3, can regulate local translation in dendritic spines.
CPEB3 monomers repress translation, whereas CPEB3 aggregates activate translation of its …
CPEB3 monomers repress translation, whereas CPEB3 aggregates activate translation of its …
[HTML][HTML] DEHP-Induced Glioblastoma in Zebrafish Is Associated with Circadian Dysregulation of PER3
S Men, J Xu, Z Yang, Z Yan - Toxics, 2024 - mdpi.com
DEHP is a plasticizer that is widely found in our water environment and poses a significant
risk to the environment and human health. Long-term exposure to DEHP can cause …
risk to the environment and human health. Long-term exposure to DEHP can cause …
Suppression of the CPEB3 ribozyme modulates the progression of glioblastoma
Glioblastoma multiforme (GBM) is the most aggressive primary malignant brain tumor in
adults, with a poor prognosis that highlights a dire clinical need for innovative therapeutic …
adults, with a poor prognosis that highlights a dire clinical need for innovative therapeutic …
Frustration In Physiology And Molecular Medicine
Molecules provide the ultimate language in terms of which physiology and pathology must
be understood. Myriads of proteins participate in elaborate networks of interactions and …
be understood. Myriads of proteins participate in elaborate networks of interactions and …