Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …

One leading hypothesis suggests that memories are stored in ensembles of neurons (or
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …

Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and
functional decline associated with age together with a particular neuropathology. It was first …

β-amyloid (Aβ)–dependent neuronal hyperactivity is believed to contribute to the circuit
dysfunction that characterizes the early stages of Alzheimer's disease (AD). Although …

In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …

Excitatory glutamatergic neurotransmission via N-methyl-d-aspartate receptor (NMDAR) is
critical for synaptic plasticity and survival of neurons. However, excessive NMDAR activity …

The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …

Alzheimer's disease is a progressive loss of memory and cognition, for which there is no
cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's …