Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …

Background: Parkinson's disease (PD) is an increasing challenge to public health. Tracking
the temporal trends of PD burden would inform health strategies. Methods: Data of PD …

Background Understanding the temporal trend of the disease burden of stroke and its
attributable risk factors in China, especially at provincial levels, is important for effective …

Largely due to population ageing, the cancer burden from older people has been rising,
which imposed considerable pressure on current Chinese healthcare system. We provide …

Importance Studies investigating the association of threat-related and deprivation-related
adverse childhood experiences (ACEs) with later-life cognitive decline are lacking …

Background Atrial fibrillation (AF) is the most common persistent cardiac arrhythmia. This
study aimed to estimate its prevalence and explore associated factors in adults aged 18 …

The concept and development of bone/cartilage organoids are rapidly gaining momentum,
providing opportunities for both fundamental and translational research in bone biology …

Recreational ecosystem service (RES) supply and demand are fundamentally influenced by
urbanization and are closely related to residents' well-being. Nevertheless, how socio …

Background Studies have shown that the prevalence of dementia in Latin America and the
Caribbean (LAC) may be higher than in high-income countries. Thus, we sought to …