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Controlling reaction specificity in pyridoxal phosphate enzymes
MD Toney - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2011 - Elsevier
Pyridoxal 5′-phosphate enzymes are ubiquitous in the nitrogen metabolism of all
organisms. They catalyze a wide variety of reactions including racemization, transamination …
organisms. They catalyze a wide variety of reactions including racemization, transamination …
Aspartate aminotransferase: an old dog teaches new tricks
MD Toney - Archives of biochemistry and biophysics, 2014 - Elsevier
Aspartate aminotransferase (AAT) is a prototypical pyridoxal 5′-phosphate (PLP)
dependent enzyme that catalyzes the reversible interconversion of l-aspartate and α …
dependent enzyme that catalyzes the reversible interconversion of l-aspartate and α …
Aromatic L-amino acid decarboxylases: mechanistic features and microbial applications
Aromatic L-amino acid decarboxylases (AADCs) catalyze the conversion of aromatic L-
amino acids into aromatic monoamines that play diverse physiological and biosynthetic …
amino acids into aromatic monoamines that play diverse physiological and biosynthetic …
NMR crystallography of a carbanionic intermediate in tryptophan synthase: chemical structure, tautomerization, and reaction specificity
Carbanionic intermediates play a central role in the catalytic transformations of amino acids
performed by pyridoxal-5′-phosphate (PLP)-dependent enzymes. Here, we make use of …
performed by pyridoxal-5′-phosphate (PLP)-dependent enzymes. Here, we make use of …
Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme
Enzymes dependent on pyridoxal 5′-phosphate (PLP, the active form of vitamin B6)
perform a myriad of diverse chemical transformations. They promote various reactions by …
perform a myriad of diverse chemical transformations. They promote various reactions by …
Role of the pyridine nitrogen in pyridoxal 5′-phosphate catalysis: activity of three classes of PLP enzymes reconstituted with deazapyridoxal 5′-phosphate
Pyridoxal 5′-phosphate (PLP; vitamin B6)-catalyzed reactions have been well studied, both
on enzymes and in solution, due to the variety of important reactions this cofactor catalyzes …
on enzymes and in solution, due to the variety of important reactions this cofactor catalyzes …
Bioinformatic analysis of the fold type I PLP‐dependent enzymes reveals determinants of reaction specificity in l‐threonine aldolase from Aeromonas jandaei
Understanding the role of specific amino acid residues in the molecular mechanism of a
protein's function is one of the most challenging problems in modern biology. A systematic …
protein's function is one of the most challenging problems in modern biology. A systematic …
Direct evidence that an extended hydrogen-bonding network influences activation of pyridoxal 5′-phosphate in aspartate aminotransferase
Pyridoxal 5′-phosphate (PLP) is a fundamental, multifunctional enzyme cofactor used to
catalyze a wide variety of chemical reactions involved in amino acid metabolism. PLP …
catalyze a wide variety of chemical reactions involved in amino acid metabolism. PLP …
Experimental and molecular modeling investigation of (E)-N-{2-[(2-hydroxybenzylidene)amino]phenyl}benzenesulfonamide
The Schiff base compound (E)-N-{2-[(2-hydroxybenzylidene) amino] phenyl}
benzenesulfonamide has been synthesized and characterized by IR, NMR and Uv-vis …
benzenesulfonamide has been synthesized and characterized by IR, NMR and Uv-vis …
Site-selective deuteration of α-amino esters with 2-hydroxynicotinaldehyde as a catalyst
J Zheng, J Tang, S **, H Hu, ZJ Jiang, J Chen… - ACS …, 2024 - ACS Publications
An efficient method has been developed for the synthesis of α-deuterated α-amino esters via
hydrogen isotope exchange of α-amino esters in D2O with 2-hydroxynicotinaldehyde as a …
hydrogen isotope exchange of α-amino esters in D2O with 2-hydroxynicotinaldehyde as a …