Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods. Here we …

Clonal selection and drift drive both normal tissue and cancer development. However, the
biological mechanisms and environmental conditions underpinning these processes remain …

The structural composition of organs undergoes significant transformations during
organogenesis, laying the foundation for their eventual functional architecture. In contrast …

Upscaling of kidney epithelial cells is crucial for renal regenerative medicine. Nonetheless,
the adult kidney lacks a distinct stem cell hierarchy, limiting the ability to long-term propagate …

Introduction Tubular epithelial cells (TECs) under adaptive state (aTECs) have been
frequently reported in the injured kidney closely associated with disease progression …

Abstracts Because of the few effective treatments for many chronic kidney diseases,
increasing consideration has been given to new regenerative therapies using stem cells …

In recent years, it has become apparent that 3D cultures of kidney cells may help maintain
cells' heterogeneity and in vivo phenotypes crucial for disease modelling and drug discovery …

During the past decades, our understanding of the way the kidney develops, functions, and
responds to damage has grown exponentially. This has resulted from the combined use of …