Localized interleukin-12 for cancer immunotherapy
Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …
Cytokines in cancer pathogenesis and cancer therapy
G Dranoff - Nature Reviews Cancer, 2004 - nature.com
The mixture of cytokines that is produced in the tumour microenvironment has an important
role in cancer pathogenesis. Cytokines that are released in response to infection …
role in cancer pathogenesis. Cytokines that are released in response to infection …
New insights into IL-12-mediated tumor suppression
S Tugues, SH Burkhard, I Ohs, M Vrohlings… - Cell Death & …, 2015 - nature.com
During the past two decades, interleukin-12 (IL-12) has emerged as one of the most potent
cytokines in mediating antitumor activity in a variety of preclinical models. Through …
cytokines in mediating antitumor activity in a variety of preclinical models. Through …
Interleukin-12 in anti-tumor immunity and immunotherapy
Interleukin-12 (IL-12) has an essential role in the interaction between the innate and
adaptive arms of immunity by regulating inflammatory responses, innate resistance to …
adaptive arms of immunity by regulating inflammatory responses, innate resistance to …
IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that …
M Chmielewski, C Kopecky, AA Hombach, H Abken - Cancer research, 2011 - AACR
During malignant progression cancer cells tend to lose cell surface expression of MHC and
other immune antigens, making them invisible to cytotoxic T cells and therefore inaccessible …
other immune antigens, making them invisible to cytotoxic T cells and therefore inaccessible …
[HTML][HTML] Symphony of nanomaterials and immunotherapy based on the cancer–immunity cycle
The immune system is involved in the initiation and progression of cancer. Research on
cancer and immunity has contributed to the development of several clinically successful …
cancer and immunity has contributed to the development of several clinically successful …
Interleukin-12: biological properties and clinical application
M Del Vecchio, E Bajetta, S Canova, MT Lotze… - Clinical Cancer …, 2007 - AACR
Abstract Interleukin-12 (IL-12) is a heterodimeric protein, first recovered from EBV-
transformed B cell lines. It is a multifunctional cytokine, the properties of which bridge innate …
transformed B cell lines. It is a multifunctional cytokine, the properties of which bridge innate …
Neutrophil-derived proteins: selling cytokines by the pound
MA Cassatella - Advances in immunology, 1999 - Elsevier
Publisher Summary This chapter summarizes the recent knowledge on the production of
cytokines by neutrophils in vitro and in vivo—particularly molecular regulation and other …
cytokines by neutrophils in vitro and in vivo—particularly molecular regulation and other …
Of CAR s and TRUCK s: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma
M Chmielewski, AA Hombach… - Immunological reviews, 2014 - Wiley Online Library
Adoptive T‐cell therapy recently achieved impressive efficacy in early phase trials, in
particular in hematologic malignancies, strongly supporting the notion that the immune …
particular in hematologic malignancies, strongly supporting the notion that the immune …
Biologic and therapeutic role of HER2 in cancer
S Menard, SM Pupa, M Campiglio, E Tagliabue - Oncogene, 2003 - nature.com
Overexpression of the human epidermal growth factor-2 (HER2) oncogene in human breast
carcinomas has been associated with a more aggressive course of disease. The reason for …
carcinomas has been associated with a more aggressive course of disease. The reason for …