Companion dogs have served an important role in cancer immunotherapy research. Sharing
similar environments and diets with humans, dogs naturally develop many of the same …

Chimeric antigen receptor (CAR) T cells are revolutionizing cancer therapy, particularly for
haematological malignancies, conferring durable and sometimes curative responses in …

The clinical potential of current FDA-approved chimeric antigen receptor (CAR)-engineered
T (CAR-T) cell therapy is encumbered by its autologous nature, which presents notable …

Unconventional T cells, including invariant natural killer T (iNKT) cells, gamma delta (γδ) T
cells, and mucosal-associated invariant T (MAIT) cells, play important roles in both innate …

Invariant natural killer T (iNKT) cells are immune cells that harness properties of both the
innate and adaptive immune system and exert multiple functions critical for the control of …

Chimeric antigen receptor (CAR) T–adoptive cell therapy has transformed the treatment of
human hematologic malignancies. However, its application for the treatment of solid tumors …

Invariant natural killer T (iNKT) cells are a conserved population of innate T lymphocytes that
are uniquely suitable as off‐the‐shelf cellular immunotherapies due to their lack of …

The strong capacity of iNKT cells to secondarily transactivate other immune cells, and to
polarize the immune response towards different functional outcomes has been clearly …

Background and Aim: Natural killer T (NKT) cells exhibit the traits of both T and NK cells.
Although their roles have been well studied in humans and mice, limited knowledge is …

Immunotherapeutic approaches to cancer treatment have gained significant traction in
recent years, due in large part to the success of immune checkpoint inhibitors and T cell …