Develo** mechanistic models has become an integral aspect of systems biology, as has
the need to differentiate between alternative models. Parameterizing mathematical models …

As modeling becomes a more widespread practice in the life sciences and biomedical
sciences, researchers need reliable tools to calibrate models against ever more complex …

Ordinary differential equation models have become a standard tool for the mechanistic
description of biochemical processes. If parameters are inferred from experimental data …

Cellular signaling processes can exhibit pronounced cell-to-cell variability in genetically
identical cells. This affects how individual cells respond differentially to the same …

Moment approximation methods are gaining increasing attention for their use in the
approximation of the stochastic kinetics of chemical reaction systems. In this paper we derive …

Motivation: In the noisy cellular environment, stochastic fluctuations at the molecular level
manifest as cell–cell variability at the population level that is quantifiable using high …

Background When conducting a meta-analysis of a continuous outcome, estimated means
and standard deviations from the selected studies are required in order to obtain an overall …

Recent progress in theoretical systems biology, applied mathematics and computational
statistics allows us to compare the performance of different candidate models at describing a …

One of the most prevalent illnesses in the world, atherosclerosis has a significant role in the
development of hypertension, stroke, myocardial localised necrosis, and several other …

Targeted mass spectrometry is a promising technology for site-specific quantification of
posttranslational modifications. However, a major constraint is the limited sensitivity for …