Advanced phenoty** of cardiovascular diseases has evolved with the application of high-
resolution omics screening to populations enrolled in large-scale observational and clinical …

Background In the early literature, unintentional vitamin C deficiency in humans was
associated with heart failure. Experimental vitamin C deficiency in guinea pigs caused …

A number of controlled trials have previously found that in some contexts, vitamin C can
have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation …

Background The LOVIT trial examined the effect of vitamin C on sepsis patients, and
concluded that in adults with sepsis receiving vasopressor therapy in the ICU, those who …

Scurvy, the condition associated with severe vitamin C deficiency, is believed to be one of
the oldest diseases in human history. It was particularly prevalent during the Age of Sail …

An 18‐year‐old man presented to our hospital with muscular pain, diffuse petechiae,
spontaneous thigh ecchymosis, edema and pain of the right knee, bilateral pretibial …

Background At least a third of the world's population consumes alcohol regularly. Patients
with alcohol use disorders (AUDs) are frequently hospitalized for both alcohol-related and …

InTroduCTIon Vitamin C, an essential water-soluble nutrient that cannot be synthesised by
humans, has a role in numerous biological reactions. 1 It is necessary for enzymatic …

Background Vitamin C deprivation can lead to fatigue, dyspnea, oedema and chest pain,
which are also symptoms of heart failure (HF). In animal studies vitamin C has improved …

In empirical studies, sudden termination of high-dose vitamin C has been shown to cause a
fall in vitamin C levels to levels below those recorded prior to the high-dose administration (1 …