The intriguing structural diversity in folded topologies available to guanine-rich nucleic acid
repeat sequences have made four-stranded G-quadruplex structures the focus of both basic …

The 3′‐ends of human chromosomal DNA terminate in short single‐stranded guanine‐rich
tandem‐repeat sequences. In cancer cells, these are associated with the telomere …

Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and
RNA G‐rich sequences are capable of forming a four‐stranded structure, known as the G …

Although cisplatin and its analogues have been widely utilized as anticancer metallodrugs
in clinics, their serious side effects and damage to normal tissues cannot be avoided …

Quadruplex nucleic acids are four-stranded structures formed from short tracts of G-rich
sequence associating together. Their formation from eukaryotic telomeric DNA sequences is …

G-rich sequences in DNA and RNA have a propensity to fold into stable secondary
structures termed G-quadruplexes. G-quadruplex forming sequences are widespread …

DNA is considered an important target for drug design and development. Until recently, the
focus was on double-stranded (duplex) DNA structures. However, it has now been shown …

G-quadruplexes are guanine-rich nucleic acids that fold by forming successive quartets of
guanines (the G-tetrads), stabilized by intra-quartet hydrogen bonds, inter-quartet stacking …

The folding of the single-stranded 3′ end of the human telomere into G-quadruplex
arrangements inhibits the overhang from hybridizing with the RNA template of telomerase …

The first X-ray crystal structures of nickel (II) and copper (II) salphen metal complexes bound
to a quadruplex DNA are presented. Two structures have been determined and show that …