This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The treatment of long-gap (> 10 mm) peripheral nerve injury (PNI) and spinal cord injury
(SCI) remains a continuous challenge due to limited native tissue regeneration capabilities …

Eukaryotic protein kinases are key regulators of cell processes. Comparison of the structures
of protein kinase domains, both alone and in complexes, allows generalizations to be made …

Protein kinase-like domains that lack conserved residues known to catalyse phosphoryl
transfer, termed pseudokinases, have emerged as important signalling domains across all …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …

Podocytes are specialized epithelial cells that cover the outer surfaces of glomerular
capillaries. Unique cell junctions, known as slit diaphragms, which feature nephrin and …

Integrin-linked kinase (ILK) is a multifunctional molecular actor in cell–matrix interactions,
cell adhesion, and anchorage-dependent cell growth. It combines functions of a signal …

Cell–matrix adhesion is crucial for maintaining the mechanical integrity of epithelial tissues.
Podocytes—a key component of the glomerular filtration barrier—are exposed to permanent …

Integrin-linked kinase (ILK) is a widely expressed and evolutionally conserved component of
cell–extracellular matrix (ECM) adhesions. Although initially named as a kinase, ILK …