Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts,
play a critical role in the compartmentalization of signaling pathways. Physical segregation …

Cell signaling does not apparently occur randomly over the cell surface, but it seems to be
integrated very often into cholesterol-rich membrane domains, termed lipid rafts. Membrane …

Cholesterol is a lipid molecule that plays an essential role in a number of biological
processes, both physiological and pathological. It is an essential structural constituent of cell …

Lipid rafts are cholesterol‐and sphingolipid‐enriched specialized membrane domains within
the plasma membrane. Lipid rafts regulate the density and activity of signal receptors by …

The accumulation of cholesterol is a general feature of cancer tissue, and recent evidence
suggests that cholesterol plays critical roles in the progression of cancers, including breast …

Introduction: The Fas/FasL system plays a significant role in tumorigenesis. Research has
shown that its impairment in cancer cells may lead to apoptosis resistance and contribute to …

Human breast cancer is one of the most frequent cancer diseases and causes of death
among female population worldwide. It appears at a high incidence and has a high …

Synthetic alkylphospholipids (ALPs), such as edelfosine, miltefosine, perifosine,
erucylphosphocholine and erufosine, represent a relatively new class of structurally related …

The Langmuir monolayer technique has been successfully used for decades to model
biological membranes and processes occurring at their interfaces. Classically, this method …

This review summarizes the cellular bases of the effects of NaCHOleate (2-hydroxyoleic
acid; 2OHOA; Minerval) against glioma and other types of tumors. NaCHOleate, activates …