Catalytic activities, molecular connections, and biological functions of plant RNA exosome complexes

H Lange, D Gagliardi - The Plant Cell, 2022 - academic.oup.com
RNA exosome complexes provide the main 3′–5′-exoribonuclease activities in eukaryotic
cells and contribute to the maturation and degradation of virtually all types of RNA. RNA …

EXOSC5 maintains cancer stem cell activity in endometrial cancer by regulating the NTN4/integrin β1 signalling axis

YH Huang, WL Wang, PH Wang… - … journal of biological …, 2024 - pmc.ncbi.nlm.nih.gov
Endometrial carcinoma (EC) is a common type of uterine cancer in developed countries,
originating from the uterine epithelium. The incidence rate of EC in Taiwan has doubled from …

RNA degradation by the plant RNA exosome involves both phosphorolytic and hydrolytic activities

N Sikorska, H Zuber, A Gobert, H Lange… - Nature …, 2017 - nature.com
The RNA exosome provides eukaryotic cells with an essential 3′–5′ exoribonucleolytic
activity, which processes or eliminates many classes of RNAs. Its nine-subunit core (Exo9) is …

RNA exosomes and their cofactors

C Kilchert - The Eukaryotic RNA Exosome: Methods and Protocols, 2020 - Springer
The RNA exosome is a ribonucleolytic multiprotein complex that is conserved and essential
in all eukaryotes. Although we tend to speak of “the” exosome complex, it should be more …

Structure and function of TatD exonuclease in DNA repair

YC Chen, CL Li, YY Hsiao, Y Duh… - Nucleic acids …, 2014 - academic.oup.com
TatD is an evolutionarily conserved protein with thousands of homologues in all kingdoms of
life. It has been suggested that TatD participates in DNA fragmentation during apoptosis in …

EXOSC5 as a novel prognostic marker promotes proliferation of colorectal cancer via activating the ERK and AKT pathways

H Pan, J Pan, S Song, L Ji, H Lv, Z Yang - Frontiers in oncology, 2019 - frontiersin.org
Background and Objective: Exosome component 5 (EXOSC5) is a novel cancer-related
gene that is aberrantly expressed in various malignances. However, the molecular …

[HTML][HTML] Genome-Wide Analysis of the RNase T2 Family and Identification of Interacting Proteins of Four ClS-RNase Genes in '**angShui' Lemon

YZ Li, JW Zhu, W Lin, MY Lan, C Luo, LM **a… - International Journal of …, 2022 - mdpi.com
S-RNase plays vital roles in the process of self-incompatibility (SI) in Rutaceae plants. Data
have shown that the rejection phenomenon during self-pollination is due to the degradation …

The exozyme model: a continuum of functionally distinct complexes

DL Kiss, ED Andrulis - Rna, 2011 - rnajournal.cshlp.org
Exosome complexes are composed of 10 to 11 subunits and are involved in multiple facets
of 3′→ 5′ RNA processing and turnover. The current paradigm stipulates that a uniform …

Endonucleases and apoptosis in animals

NI Aleksandrushkina, BF Vanyushin - Biochemistry (Moscow), 2012 - Springer
Endonucleases are the main instruments of obligatory DNA degradation in apoptosis. Many
endonucleases have marked processive action; initially they split DNA in chromatin into very …

Polyadenylated versions of small non-coding RNAs in Saccharomyces cerevisiae are degraded by Rrp6p/Rrp47p independent of the core nuclear exosome

A Chaudhuri, S Paul, M Banerjea, B Das - Microbial Cell, 2024 - pmc.ncbi.nlm.nih.gov
In Saccharomyces cerevisiae, polyadenylated forms of mature (and not precursor) small non-
coding RNAs (sncRNAs) those fail to undergo proper 3′-end maturation are subject to an …