Regulation of mitochondrial ATP production: Ca2+ signaling and quality control
Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …
Cardiac mechano-electric coupling: acute effects of mechanical stimulation on heart rate and rhythm
The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …
continually throughout our life, supplying the body with oxygen and nutrients while removing …
Vitamin D cell signalling in health and disease
MJ Berridge - Biochemical and biophysical research communications, 2015 - Elsevier
Vitamin D deficiency has been linked to many human diseases such as Alzheimer's disease
(AD), Parkinson's disease (PD), multiple sclerosis (MS), hypertension and cardiovascular …
(AD), Parkinson's disease (PD), multiple sclerosis (MS), hypertension and cardiovascular …
Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations
Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with
increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates …
increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates …
Mechanisms of myofascial pain
Myofascial pain syndrome is an important health problem. It affects a majority of the general
population, impairs mobility, causes pain, and reduces the overall sense of well‐being …
population, impairs mobility, causes pain, and reduces the overall sense of well‐being …
Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle
In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress
transduced by the microtubule network elicits reactive oxygen species. X-ROS tunes Ca2+ …
transduced by the microtubule network elicits reactive oxygen species. X-ROS tunes Ca2+ …
The role of mitochondrial reactive oxygen species, NO and H2S in ischaemia/reperfusion injury and cardioprotection
Redox signalling in mitochondria plays an important role in myocardial
ischaemia/reperfusion (I/R) injury and in cardioprotection. Reactive oxygen and nitrogen …
ischaemia/reperfusion (I/R) injury and in cardioprotection. Reactive oxygen and nitrogen …
[HTML][HTML] Cardiac pathophysiology and the future of cardiac therapies in Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a devastating disease featuring skeletal muscle
wasting, respiratory insufficiency, and cardiomyopathy. Historically, respiratory failure has …
wasting, respiratory insufficiency, and cardiomyopathy. Historically, respiratory failure has …
Reactive oxygen species as intracellular signaling molecules in the cardiovascular system
AV Krylatov, LN Maslov, NS Voronkov… - Current cardiology …, 2018 - benthamdirect.com
Background: Redox signaling plays an important role in the lives of cells. This signaling not
only becomes apparent in pathologies but is also thought to be involved in maintaining …
only becomes apparent in pathologies but is also thought to be involved in maintaining …
Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD (P) H oxidases
The production of reactive oxygen and nitrogen species (RONS) by skeletal muscle is
important as it (i) underlies oxidative damage in many degenerative muscle pathologies and …
important as it (i) underlies oxidative damage in many degenerative muscle pathologies and …