ABSTRACT Introduction Recently, the European Medicines Agency (EMA) received reports
of suicidal thoughts and self-injury associated with glucagon-like peptide-1 receptor …

Type 2 diabetes and major depressive disorder (MDD) are the leading causes of disability
worldwide and have a high comorbidity rate with fatal outcomes. Despite the long …

The pathological condition of insulin resistance prevents the neuroprotective effects of
insulin. Numerous studies have demonstrated that insulin resistance, as an independent risk …

Survival under selective pressure is driven by the ability of our brain to use sensory
information to our advantage to control physiological needs. To that end, neural circuits …

Introduction The roles of metabolic signals, including Glucagon-like peptide 1 (GLP-1), have
been implicated in multiple domains outside metabolic regulation. There is a growing …

Abstract Purpose of Review To highlight the added benefits of approved and upcoming,
centrally-acting, anti-obesity drugs, focusing not only on the most common metabolic and …

Eating behaviors are influenced by the reinforcing properties of foods that can favor
decisions driven by reward incentives over metabolic needs. These food reward-motivated …

There is significant evidence linking a 'reward deficiency syndrome'(RDS), comprising
decreased availability of striatal dopamine D2-like receptors (DD2lR) and addiction-like …

Objective In obesogenic states and after exercise, interleukin (IL)‐6 elevations are
established, and IL‐6 is speculated to be an appetite‐regulating mechanism. This study …

Obesity is a critical health condition worldwide that increases the risks of comorbid chronic
diseases, but it can be managed with weight loss. However, conventional interventions …