Perinatal group B streptococcal infections: virulence factors, immunity, and prevention strategies

J Vornhagen, KMA Waldorf, L Rajagopal - Trends in microbiology, 2017 - cell.com
Group B streptococcus (GBS) or Streptococcus agalactiae is a β-hemolytic, Gram-positive
bacterium that is a leading cause of neonatal infections. GBS commonly colonizes the lower …

Bacterial and host determinants of group B streptococcal vaginal colonization and ascending infection in pregnancy

A Brokaw, A Furuta, M Dacanay… - Frontiers in cellular …, 2021 - frontiersin.org
Group B streptococcus (GBS) is a gram-positive bacteria that asymptomatically colonizes the
vaginal tract. However, during pregnancy maternal GBS colonization greatly predisposes …

Extracellular Vesicles-mediated recombinant IL-10 protects against ascending infection-associated preterm birth by reducing fetal inflammatory response

AK Kammala, A Mosebarger, E Radnaa… - Frontiers in …, 2023 - frontiersin.org
Background Fetal inflammatory response mediated by the influx of immune cells and
activation of pro-inflammatory transcription factor NF-κB in feto-maternal uterine tissues is …

Human β‐defensin‐1: A natural antimicrobial peptide present in amniotic fluid that is increased in spontaneous preterm labor with intra‐amniotic infection

A Varrey, R Romero, B Panaitescu… - American journal of …, 2018 - Wiley Online Library
Problem Human β‐defensins (HBD s) are antimicrobial peptides that participate in the
soluble innate immune mechanisms against infection. Herein, we determined whether HBD …

Sex-specific maternofetal innate immune responses triggered by group B Streptococci

MJ Allard, A Giraud, M Segura, G Sebire - Scientific reports, 2019 - nature.com
Abstract Group B Streptococcus (GBS) is one of the most common bacteria isolated in
human chorioamnionitis, which is a major risk factor for premature birth and brain injuries …

miRNA‐126 enhances viability, colony formation, and migration of keratinocytes HaCaT cells by regulating PI3 K/AKT signaling pathway

L Chang, J Liang, X **a, X Chen - Cell biology international, 2019 - Wiley Online Library
Wound healing is a basic biological process including proliferation and migration of
keratinocyte. The effects of microRNAs on skin wound healing remain largely unexplored …

Decidual stromal cell‐derived PGE2 regulates macrophage responses to microbial threat

LM Rogers, AP Anders, RS Doster… - American journal of …, 2018 - Wiley Online Library
Problem Bacterial chorioamnionitis causes adverse pregnancy outcomes, yet host‐microbial
interactions are not well characterized within gestational membranes. The decidua, the …

Effect of MicroRNA-146a modified adipose-derived stem cell exosomes on rat back wound healing

G Chen, MD, Y Wu, MD, L Zou, MD… - … Journal of Lower …, 2023 - journals.sagepub.com
Objective: To investigate the effect of MicroRNA-146a modified adipose-derived stem cell
exosomes on the proliferation and migration of fibroblasts and the therapeutic effect on …

Frontiers in the etiology and treatment of preterm premature rupture of membrane: from molecular mechanisms to innovative therapeutic strategies

L Xu, T Yang, M Wen, D Wen, C **, M An, L Wang… - Reproductive …, 2024 - Springer
Preterm premature rupture of membranes (pPROM) poses a significant threat to fetal viability
and increases the risk for newborn morbidities. The perinatal period of preterm infants …

Protein kinase D mediates inflammatory responses of human placental macrophages to Group B Streptococcus

JA Sutton, LM Rogers, BREA Dixon… - American Journal of …, 2019 - Wiley Online Library
Problem During pregnancy, Group B Streptococcus (GBS) can infect fetal membranes to
cause chorioamnionitis, resulting in adverse pregnancy outcomes. Macrophages are the …