Concepts in sumoylation: a decade on

R Geiss-Friedlander, F Melchior - Nature reviews Molecular cell biology, 2007 - nature.com
A decade has passed since SUMO (small ubiquitin-related modifier) was discovered to be a
reversible post-translational protein modifier. During this time many enzymes that participate …

SUMO: from bench to bedside

HM Chang, ETH Yeh - Physiological Reviews, 2020 - journals.physiology.org
Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates
multiple biological processes, including cell division, DNA replication/repair, signal …

SUMO: a history of modification

RT Hay - Molecular cell, 2005 - cell.com
The small ubiquitin-like modifier (SUMO) is covalently linked to a variety of proteins and is
deconjugated by SUMO-specific proteases. A characteristic of SUMO modification is that the …

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

JR Gareau, CD Lima - Nature reviews Molecular cell biology, 2010 - nature.com
Proteins of the small ubiquitin-related modifier (SUMO) family are conjugated to proteins to
regulate such cellular processes as nuclear transport, transcription, chromosome …

Sumoylation: a regulatory protein modification in health and disease

A Flotho, F Melchior - Annual review of biochemistry, 2013 - annualreviews.org
Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now
established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds …

[HTML][HTML] The post-translational modification, SUMOylation, and cancer

ZJ Han, YH Feng, BH Gu, YM Li… - … journal of oncology, 2018 - spandidos-publications.com
SUMOylation is a reversible post-translational modification which has emerged as a crucial
molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune …

Mechanisms, regulation and consequences of protein SUMOylation

KA Wilkinson, JM Henley - Biochemical Journal, 2010 - portlandpress.com
The post-translational modification SUMOylation is a major regulator of protein function that
plays an important role in a wide range of cellular processes. SUMOylation involves the …

Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts

AB Celen, U Sahin - The FEBS journal, 2020 - Wiley Online Library
Sumoylation is an essential post‐translational modification intimately involved in a diverse
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …

Targeting the ubiquitin system in cancer therapy

D Hoeller, I Dikic - Nature, 2009 - nature.com
The ubiquitin system is a network of proteins dedicated to the ubiquitylation of cellular
targets and the subsequent control of numerous cellular functions. The deregulation of …

SUMO conjugation–a mechanistic view

A Pichler, C Fatouros, H Lee, N Eisenhardt - Biomolecular concepts, 2017 - degruyter.com
The regulation of protein fate by modification with the small ubiquitin-related modifier
(SUMO) plays an essential and crucial role in most cellular pathways. Sumoylation is highly …