Tumor abnormality-oriented nanomedicine design

Q Zhou, J **ang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

H Zhou, L Zhu, J Song, G Wang, P Li, W Li, P Luo… - Molecular cancer, 2022 - Springer
Colorectal cancer (CRC) is one of the most common cancers worldwide and a leading
cause of carcinogenic death. To date, surgical resection is regarded as the gold standard by …

Cancer-associated fibroblasts: overview, progress, challenges, and directions

Q **, R Yan, X Cheng, W Wang, Y Zhong… - Cancer gene …, 2021 - nature.com
Tumors are one of the main causes of death in humans. The development of safe and
effective methods for early diagnosis and treatment of tumors is a difficult problem that needs …

Strategies to improve the EPR effect: A mechanistic perspective and clinical translation

M Ikeda-Imafuku, LLW Wang, D Rodrigues… - Journal of Controlled …, 2022 - Elsevier
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

Stromal cells in the tumor microenvironment: accomplices of tumor progression?

Y Zhao, M Shen, L Wu, H Yang, Y Yao, Q Yang… - Cell Death & …, 2023 - nature.com
The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular
component), and cellular components include cancer cells and non-malignant cells such as …

Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting

R Rimal, P Desai, R Daware, A Hosseinnejad… - Advanced drug delivery …, 2022 - Elsevier
The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …

Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma

W Pu, X Shi, P Yu, M Zhang, Z Liu, L Tan, P Han… - Nature …, 2021 - nature.com
The tumor ecosystem of papillary thyroid carcinoma (PTC) is poorly characterized. Using
single-cell RNA sequencing, we profile transcriptomes of 158,577 cells from 11 patients' …

Advances in nanomaterial-based targeted drug delivery systems

X Cheng, Q **e, Y Sun - Frontiers in bioengineering and …, 2023 - frontiersin.org
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …

Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy

F Galli, JV Aguilera, B Palermo, SN Markovic… - Journal of experimental …, 2020 - Springer
Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are
able to evade the immune response and establish a very complex balance in which different …

Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix

EJ Kay, K Paterson, C Riera-Domingo, D Sumpton… - Nature …, 2022 - nature.com
Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated
fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a …